You should always have a couple of questions for the interviewer, but don’t make it a game of 20 Questions. This is your chance to “interview” the company to see if it’s a good fit for you, and it lets you show what you know about them.
Ask a specific question about any recent news they’ve made, but stay away from any negative headlines.
Also, ask a specific question about the office culture and the team that you would be working with. This will cause the interviewer to create a mental image in their head of you actually working in the office. It helps to make you memorable when they are reviewing all of the candidates later.